Combination of direct information methods and alignments improves contact prediction.


The newest version of PconsC can be retrived from GitHub repository:


Snapshot of PconsC reported in the paper, can be downloaded here.

The stable version, that should be used for production use (if desired), can be downloaded here

Software should run well on its own, albeit it requires a Python interpreter. Prediction, given just a sequence, requires working installation of jackhmmer (and a BLAST formatted sequence database), as well as working installation of HHblits with a respective database. Afterwards, PconsC needs a PSICOV executable and a functioning MATLAB installation.

If you happen to run into any problems, do not hesitate to contact the author – Marcin Skwark, at e-mail address firstname@lastname.pl (that is m[…]@s[…].pl).